Alteration of gentamicin and cefazolin kinetics with control of the hypothyroid state in humans.

نویسندگان

  • P Chanson
  • V Joly
  • A Contrepois
  • J J Garaud
  • J Bauchet
  • J Mohler
  • P C Nguyen
  • C Carbon
چکیده

We studied the effect of the control of the hypothyroid state in humans on the pharmacokinetic parameters of cefazolin and gentamicin after a single intravenous injection. These two antibiotics were chosen because of their different patterns of binding to serum albumin (0% for gentamicin and 82% for cefazolin). In hypothyroidism, the behavior of cefazolin only was altered, with a decrease in the total body clearance, possibly due to reduced urinary excretion, and a decrease in the volume of distribution without a significant alteration of cefazolin binding to serum protein.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

مقایسه سفازولین تنها و همراه با جنتامایسین در پیشگیری از عفونت محل جراحی در بیماران تحت عمل جراحی پیوند عروق کرونر

Background and purpose: Surgical site infection (SSI) is the third leading cause of hospital infections which results in increased morbidity, mortality and costs after cardiac surgery. The importance of prophylactic antibiotics in cardiac surgery has been proved. The aim of this randomized clinical trial was to compare two prophylactic antibiotic regimens (cefazolin and cefazolin plus gentamici...

متن کامل

Alteration in postnatal development of masseter innervation in hypothyroid rats

The thyroid hormones have profound effects on the development of neuromuscular system. These hormones exert their influence on both muscle fibers and related motoneurons during development. Masseter is one of the most important muscles for mastication in mammals. Thyroid hormone deficiency 3 weeks after birth, the period in which an alteration from sucking to biting occurs, could influence the ...

متن کامل

Alteration in postnatal development of masseter innervation in hypothyroid rats

The thyroid hormones have profound effects on the development of neuromuscular system. These hormones exert their influence on both muscle fibers and related motoneurons during development. Masseter is one of the most important muscles for mastication in mammals. Thyroid hormone deficiency 3 weeks after birth, the period in which an alteration from sucking to biting occurs, could influence the ...

متن کامل

The effect of thyroid activity on adult rat spermatogenesis

The influence of hypo- and hyper-thyroidism on spermatogenesis was studied in 60-day-old adult maleWistar rats. To confirm hypo- and hyper-thyroidism, the concentration of plasma thyroid hormones wereassayed by radioimmunoassay. The hypothyroid state, induced by administration of 25 mg/kg/daymethimazole for 5 successive days, resulted in significant decrease in the number of Sertoli cells, sper...

متن کامل

Nephrotoxicity of cephalosporin-gentamicin combinations in rats.

TO STUDY THE POSSIBILITY THAT CEPHALOSPORINS AUGMENT THE NEPHROTOXICITY OF GENTAMICIN, GROUPS OF RATS WERE GIVEN FOUR HOURLY SUBCUTANEOUS DOSES OF: gentamicin (5 mg/kg), gentamicin plus cephalothin (100 mg/kg), gentamicin plus cefazolin (20 mg/kg), gentamicin plus cefazolin (50 mg/kg), gentamicin plus cephaloridine (50 mg/kg), or saline diluent for 15 days. Periodic measurements were made of ur...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 31 4  شماره 

صفحات  -

تاریخ انتشار 1987