Alteration of gentamicin and cefazolin kinetics with control of the hypothyroid state in humans.
نویسندگان
چکیده
We studied the effect of the control of the hypothyroid state in humans on the pharmacokinetic parameters of cefazolin and gentamicin after a single intravenous injection. These two antibiotics were chosen because of their different patterns of binding to serum albumin (0% for gentamicin and 82% for cefazolin). In hypothyroidism, the behavior of cefazolin only was altered, with a decrease in the total body clearance, possibly due to reduced urinary excretion, and a decrease in the volume of distribution without a significant alteration of cefazolin binding to serum protein.
منابع مشابه
مقایسه سفازولین تنها و همراه با جنتامایسین در پیشگیری از عفونت محل جراحی در بیماران تحت عمل جراحی پیوند عروق کرونر
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 31 4 شماره
صفحات -
تاریخ انتشار 1987